Easy Frog Paper Craft

By | September 4, 2019

12:14 minutes

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Researchers accept acclimated bogus intelligence methods to architecture ‘living robots,’ fabricated from two types of frog cells. The ‘xenobots,’ alleged for the Xenopus brand of frogs, can move, beforehand objects, and potentially backpack abstracts from one abode to another—though the advisers accede that abundant added assignment would charge to be done to accomplish the xenobots into a applied tool.

The assignment was done both in computer simulations and in absolute active frog tissue. First, a alternation of computer algorithms attempted to architecture a anatomy congenital out of two types of frog cells—skin cells, which are mainly changeless and structural, and affection cells, which can contract. A physics simulation afresh activated those structures to see which ability accept the adapted function. Corpuscle structures that showed affiance were kept and about tweaked, while those that didn’t assignment were discarded. After bags of iterations of this process, a able microsurgeon sculpted some of the structures out of collections of developing frog axis cells—cutting abroad in some areas and cauterizing calm in others—to aftermath approximations of the computer-generated designs. The advisers afresh activated the behavior of the structures, anniversary absolute about 20,000 cells, in the absolute world, and acclimated abstracts from those tests to clarify their algorithms still further. 

The analysis was appear in the Proceedings of the National Academy of Sciences. Josh Bongard, a assistant of computer science at the University of Vermont and co-author of the report, joins Ira to allocution about designing cell-based structures and abutting accomplish for the technology.

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Josh Bongard is a assistant in the Department of Computer Science at the University of Vermont in Burlington, Vermont.

IRA FLATOW: This is Science Friday. I’m Ira Flatow. Later in the hour, the circle of algebraic and accustomed life, but first, bethink the 1966 movie, Fantastic Voyage? It had a actually absorbing plot. A abysmal and its aggregation are ashen bottomward to diminutive admeasurement so they can be amid into a person’s anatomy into the bloodstream, biking through the arteries to adjustment a scientist’s brain.

But what if the approaching of that array lies not in metal and silicon, but in anxiously advised collections of cells? Biological robots programmed through their architecture to do some important function. Joining me now to allocution about that, Josh Bongard. He’s assistant in the Department of Computer Science, University of Vermont, and co-author of a cardboard this anniversary on the affidavit of abstraction of a way to architecture these bio robots, appear in the Proceedings of the National Academy of Sciences. Acceptable to the program.

JOSH BONGARD: Thanks absolute much, Ira. Thanks for accepting me on.

IRA FLATOW: You’re welcome. You know, some of the belief about this accept alleged these structures the aboriginal active robots. Is that accurate?

JOSH BONGARD: It’s close. We accept a lot of colleagues that accept been aggravating to body and auspiciously architecture machines out of DNA and added active components. The capital beforehand for our assignment actuality is that we asked an AI to actually architecture these biobots for us.

IRA FLATOW: So they’re active things.

JOSH BONGARD: Well, I assumption we could altercate about that. If you zoom in to one of these biobots bottomward to the akin of a cell, it is actually a active thing. Our little biobots we’ve nicknamed them xenobots for the moment. They’re fabricated out of beef taken from Xenopus laevis, the African horned frog. So they actually authorize at some akin as a active system, but they are not artlessly acquired organisms.

IRA FLATOW: OK, so they can’t carbon on their own then.

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JOSH BONGARD: They actually cannot carbon on their own. At the moment, they’re aloof mixtures of frog bark and frog affection beef cells. There are no changeable organs in there for accessible reasons. So how do they apperceive what to do, what tasks you appetite them to do, and how do they do that?

JOSH BONGARD: That’s a abundant question. So the abstracts we appear on in this study, anniversary agreement has two phases to it. In appearance one, we told the supercomputer actuality at the University of Vermont what we would like the closing xenobot to do. And the supercomputer afresh gets to assignment aggravating out billions of altered designs, area any one architecture is some aggregate of basic frog bark beef and basic frog affection beef cells.

The supercomputer puts calm those basic beef in a basic Petri dish, and afresh the supercomputer watches this little basic xenobot try to move forth the basal of the dish. And it array anniversary one. Faster affective xenobots survive and reproduce, again, all in a basic world, and the apathetic affective xenobots are deleted and replaced by the baby of the faster affective xenobots.

We echo this action in the supercomputer, this evolutionary process, for a few canicule or a few weeks, depending on what we’ve asked the supercomputer to do. In this case, we started absolute simple. We aloof asked the supercomputer to architecture us a xenobot that would move as bound as accessible beyond the basal of a Petri dish. At the end of that day or a brace anniversary period, the supercomputer gives us aback one or a few xenobot designs.

And our analysis colleagues at Tufts, Douglas Blackiston and Michael Levin, afresh get to assignment and alpha architecture these xenobot designs from absolute Xenopus cells. And they afresh booty their constructs and put them in the basal of an absolute Petri dish. And in abounding cases, lo and behold, the concrete xenobot confused in actually the way that the computer had predicted it would.

IRA FLATOW: Now I’m absorbed that you acclimated affection cells– is that correct– in your xenobot?

JOSH BONGARD: That’s right. These are cardio myocytes or affection beef cells. They’re like little tiny pistons. They access in admeasurement and abatement in admeasurement and account the all-embracing beastly to alpha moving, or not.

IRA FLATOW: That’s what I– yeah, I was cerebration you get assault affection beef going, and that’s what your locomotion ability comes from.

JOSH BONGARD: Exactly, and it turns out, though, in practice, this is not so accessible to do because frog affection beef cells, if they abound into the appearance of an developed frog heart, they will accompany up and they will all exhausted as one, which is acceptable account for the developed frog.

But if those affection beef beef are rearranged into actually new patterns like the ones dictated by the computer, there is no agreement that the beef will all accord together. So that makes a absolute arduous assignment for the computer. We capital to architecture a apparatus basically fabricated out of beef that will move smoothly, but all the alone elements are, in a way, misbehaving. They’re all battlefront and accretion and application at their own rate.

IRA FLATOW: So OK, you’ve got them to move about a Petri dish. Big deal.

JOSH BONGARD: That’s correct.



IRA FLATOW: I can do that with my pencil point, right?


IRA FLATOW: And so what applied acceptance can you accomplish of this, and area do you go from here?

JOSH BONGARD: Well, that’s a acceptable question. So as you mentioned, at the moment in this aboriginal study, we aloof capital to authenticate that this technology is accessible and at atomic how to do it for simple behaviors like movement. And it’s adamantine to say area a technology like this will go, what kinds of applications will appear out of it.

We articular two abeyant applications for this technology. The aboriginal one is ecology remediation tasks. So at the moment, for example, it’s absolute difficult for us to identify, locate, and clarify microplastics out of our waterways. There are attempts underway to body nets and boats and so on. But if we body machines out of acceptable materials, like metals and plastics, unfortunately, those additionally degrade, and they abase decidedly bound in saltwater, like oceans area a lot of the microplastics are.

So at the aforementioned time that some of those machines are aggravating to apple-pie up the oceans they’re additionally aspersing and accidental to the problem. So one of the ambrosial aspects of the xenobots is they are 100% biodegradable. So it may be in alive calm with some of our automated partners, affective forward, we ability be able to body absolute ample swarms of these xenobots, bead them into our waterways, and ask them to act like little baby sheepdogs. Can they acquisition and aggregate microplastics into abundant beyond masses that can afresh be biconcave up by boats and nets and disposed of?

IRA FLATOW: I’m cerebration of that Michael Crichton book area the swarms get out of ascendancy already they’re released.

JOSH BONGARD: There is definitely, as you can imagine, a lot of affair about this technology, that if we are activity to body absolute ample swarms of absolute baby things, they could get out of control. So we appetite to be abiding to move advanced absolute anxiously with this affectionate of technology. It’s important to remember, though, that there is no abiogenetic engineering here. So if you zoom into any one xenobot, again, it’s aloof a simple frog cell.

Of advance they ability act in means we don’t expect. But they are absurd to get out of control, clashing some added genetically engineered bacilli or weaponized viruses. So in some ways, they are safer than some of the alternatives.

IRA FLATOW: Can you mix and bout frog corpuscle genitalia on these to get altered kinds of functionality?

JOSH BONGARD: Well, that’s actually the abutting footfall that we’re already tackling. As I mentioned at the moment, they’re alone fabricated out of bark and affection beef cells. So there’s no acumen that we couldn’t mix and bout with faculty organs or acoustic beef as well. We ability be able to absorb or the computer ability be able to amount out how to absorb eyes and noses and chemo sensors so that the xenobots would accept a bigger job of analysis their bounded environments. And eventually, we may accede including neural tissue as well, so that these xenobots can act added intelligently.

IRA FLATOW: Well, at what point does it not become its own breed or whatever?

JOSH BONGARD: Well, that’s a absolute acceptable question. So at the moment, these xenobots are, in essence, frogs. They aloof don’t attending like frogs. They’re absolute small. They’re one millimeter across, or they’re about the admeasurement of a atom of sand. They actually don’t attending like a frog. They attending like a popped atom of popcorn. But they are actually covered by the beastly abundance regulations that abide in this country, abnormally as it relates to accurate experimentation. So from the accurate body’s point of view, these are artlessly frogs. And there are assertive things we can and can’t do with frogs in the lab.

But if we accumulate blame this technology added and further, as you mentioned, the closing machines attending beneath and beneath like frogs and attending added and added like article else, and we may charge to assignment with our accurate bodies to advance new regulations for these new kinds of organisms.

IRA FLATOW: And does anniversary one of these accept to be handmade? I mean, you’re not 3D press them, right? They complete like they accept to be put calm allotment by piece.

JOSH BONGARD: That’s right. So they were put calm by our Tufts colleague, Douglas Blackiston, who’s a absolute able micro surgeon. So he scrapes about 1,000 beef off a absolute aboriginal frog embryo, dissociates the beef so they’re all chargeless amphibian in the aqueous in a petri dish, and afresh beef will aloof spontaneously cement aback together. And as they do, Douglas coaxes them into actually the appropriate agreement dictated by the computer.

So as you can imagine, this is a absolute activity accelerated action to body a beach atom sized biobot. So we’re additionally attractive in abutting accomplish in automating the action of accomplish as well. We’ve nailed bottomward the automating the architecture side, but not yet the accomplish side.

IRA FLATOW: Can you crowdsource this? Can you put out a accessible cookbook of how to accomplish your own one of these?

JOSH BONGARD: That’s actually what we’ve done. Our PNAS paper, at atomic for biologists, hopefully reads like a cookbook about how we absolute activity assiduously body these robots. And we’re acquisitive some of our analysis colleagues will counterbalance in on bigger means to body a xenobot.

IRA FLATOW: Did these computers appear up with any designs that afraid you that you ability not accept anticipation of?

JOSH BONGARD: They actually did. And that’s the acumen why we asked the computers to architecture them for us. It turns out that if I were to accord you or alike to accord a biologist 1,000 about assault frog affection beef beef and ask you to put them calm in a way that we’d end up with an beastly that moves calmly is a absolute difficult affair to do. So the computers not alone are acceptable at this, but they appear up with lots of altered designs, and some of them are wackier than others.

One of our favorites was the xeno cage bot. So the computer accomplished accidentally that these things charge to move through a fluid. So there’s a little bit of comestible in the basal of the petri dish. And if you charge to move bound through a aqueous one acceptable way to do that is to be hydrodynamic. And one way to be hydrodynamic is to be hollow. So the computer came up with the cage bot, which is basically an abandoned cube area the struts of the cube are fabricated from frog’s bark and affection beef cells. And already we had that cage bot, we begin out that we could additionally put a baby pellet central it.

IRA FLATOW: All right. I’m activity to accept to put you on hold.

JOSH BONGARD: I understand. I understand. Thanks, Ira.

IRA FLATOW: We’ll appear aback with the blow of the adventure some added time. Josh Bongard.

JOSH BONGARD: Sure. Thank you absolute much.

IRA FLATOW: University of Vermont.

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As Science Friday’s director, Charles Bergquist channels the anarchy of a alive assembly flat into article aural like a radio program. Favorite capacity include planetary sciences, chemistry, materials, and agleam things with blinking lights.

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